The ratio of peripheral CD4+ cells and CD8+ cells significantly increased at 2 weeks after tumor inoculation in group F (CD4+ (%), p = 0.0003; CD8+ (%), p = 0.0002) and group G (CD4+ (%), p = 0.007; CD8+ (%), p = 0.014) when compared with group H (Fig. 4b, c). Here, CD8A is linked to neoplasm.