Consistent with previous reports [48, 49] that associated the Nrf2 pathway with SFN-induced chemoprevention, we found that the Nrf2 target genes HMOX1, TXNRD1, GCLC, GCLM, AKR1B10 and G6PD were upregulated after melanoma treatment. Here, AKR1B10 is linked to melanoma.