SCN2A and Epileptic encephalopathy: Among the subset of novel SCN2A missense variants in Wolff et al. (2017) that qualified as having occurred de novo and restricting to severe epileptic encephalopathies, we observed a shift toward higher GPP scores (n = 24; median GPP score of 0.82) compared to the remaining novel missense variants (n = 28; median GPP score of 0.64; Mann-Whitney U test, P = 0.02).