For five epilepsy genes GRIN2A (CADD), KCNT1 (VEST3), LGI1 (VEST3), SLC2A1 (MutationAssessor), and STXBP1 (VEST3), there was no evidence in the current sample to support the addition of features beyond the gene's top ranked feature (Supplemental Table S5). Here, LGI1 is linked to epilepsy.