We find current evidence for this preferential enrichment among six epilepsy genes: CDKL5 (P = 1.1 × 10−12), KCNQ2 (P = 1.1 × 10−23), PCDH19 (P = 0.003), SCN1A (P = 9.7 × 10−9), SCN2A (P = 1.9 × 10−4), and SCN8A (P = 3.5 × 10−4) (Table 1). This evidence concerns the gene CDKL5 and epilepsy.