CDKL5 and epilepsy: We selected 11 dominant epilepsy genes (EpiPM Consortium 2015) of which each had at least 20 epilepsy-associated “pathogenic” missense variants among the combination of ClinVar (accessed May 1st 2016) and HGMD (hgmd2016.3) variant databases (Supplemental Table S1): CDKL5, GRIN2A, KCNQ2, KCNT1, LGI1, PCDH19, SCN1A, SCN2A, SCN8A, SLC2A1, and STXBP1.