IGF1R and cancer: Also there is evidence regarding the importance in cancer development of other targets of miRNA-148a, such as DNMT1 – inhibition of which increases expression of multiple genes by epigenetic changes (reduced methylation) [36]; ERBB3 – involved in angiogenesis [37]; CDC25B – cell cycle regulator [38]; and IGF-IR, AKT, MAPK/ERK – cell growth [39].