BRCA1 and breast carcinoma: BRCA1 IHC staining was lower in breast cancer cases than normal breast tissue in both the cytoplasmic (cancer: 39.2±1.9; Normal: 58.5±3.9, p = 0.037) and nuclear fractions (cancer: 65.4±2.3; normal: 81.8±4.4, p = 0.007) (Table 4).