BRCA1 and invasive breast carcinoma: In normal breast tissue samples, BRCA1 expression was modestly higher in the nucleus than the cytoplasm (156 ± 6 versus 151 ± 8, respectively; p = 0.02, N/C ratio = 1.15±0.1) while in invasive breast cancer samples, a higher BRCA1 expression in the nucleus than in the cytoplasm was more pronounced (141 ± 3 versus 118 ± 3, respectively, p<0.0001, N/C ratio = 1.5±0.1).