Marionneau et al. found that in aortic coarctation-induced cardiac hypertrophy, there were no significant differences in the amplitudes of Ito, IK,slow, and IK1 between cardiomyocytes in the endo-myocardium and those in the epi-myocardium, and there was no transmural spatial heterogeneity in the expression of channel proteins, Ito (Kv4.2, Kv4.3, KChIP2), IK1 (Kir2.1, Kir2.2), and Iss (TASK1, TASK2). Here, KCNK5 is linked to aorta coarctation.