CRP and osteoarthritis: Another observational study demonstrated that administration of RE and oleanolic acid (440 mg thrice a day for four weeks and additional 880 mg twice a day for four weeks) in patients with osteoarthritis, fibromyalgia, and rheumatoid arthritis was protective against inflammatory rheumatic diseases, particularly in those with initial serum c-reactive protein (CRP) levels >7.0 mg/L (Table 7) [75].