The most frequently methylated genes in cervical cancer are cell adhesion molecule 1 (CADM1), cadherin 1 (CDH1), death-associated protein kinase 1 (DAPK1), EPB41L3, FAM1A4, myelin and lymphocyte (MAL), paired box 1 (PAX1), PR domain containing 14 (PRDM14,) and telomerase reverse transcriptase (hTERT) [52,58,59], however a single gene target has not proven amenable as a biomarker [52] indicating that a panel of methylated genes may be more useful. The gene discussed is CDH1; the disease is cervical cancer.