Interestingly, HPV E7-expressing and some cervical cancer cells are “addicted” to the expression of p16INK4A, suggesting that the biological activity of p16INK4A in HPV-associated cancers is more like that of an oncogene, as opposed to its well-established role as a tumor suppressor in most other human cancer types [74]. This evidence concerns the gene CDKN2A and neoplasm.