Honeyman et al discovered a novel somatic recurrent 400 kb deletion on the short arm of chromosome 19, giving rise to an in-frame DNAJB1–PRKACA gene fusion in fibrolamellar carcinoma.7 The resulting fusion protein is thought to constitutively activate the kinase activity of protein kinase A catalytic subunit alpha and to function as the oncogenic driver of fibrolamellar carcinoma. The gene discussed is PRKACA; the disease is fibrolamellar hepatocellular carcinoma.