Attempts to address this problem began with the report of overexpression of anterior gradient-2 protein as a marker of fibrolamellar carcinoma15 and continued with studies showing the utility of CD68 and cytokeratin 7 co-expression in confirming a histological diagnosis of fibrolamellar carcinoma.3 While immunostains for CK7 and CD68 are widely available and easy to use, the CD68 stain in particular can fail in some cases for technical reasons. Here, CD68 is linked to fibrolamellar hepatocellular carcinoma.