Taking into consideration that leptin at a supraphysiological concentration, as noted in obese women, has stimulatory effects on testosterone secretion characteristic of polycystic ovarian syndrome correlated with obesity [12], we hypothesised that, as in the case of epithelial ovarian cancer, ObR overexpression in granulosa cell tumours could be correlated with the incidence of granulosa cell cancer, and leptin receptor blockers might be used as an adjuvant therapy. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.