CNR1 and migraine disorder: CSD has been shown to be a result of excessive glutamate signaling, and one effect of endocannabinoids is the suppression of glutamate signaling via the inhibition of NMDA receptors.74 In fact, suppression of CSD has been achieved by THC and cannabinoid CB1 agonist activation of CB1 receptors in murine models.75 This suggests a use for cannabis in the prevention of the initial mechanisms triggering a migraine aura and the subsequent pain.