1,34 2-AG induced the migration of human eosinophils in a CB2-dependent manner, where such receptor was particularly expressed, although less potently than typical, strong eosinophil chemoattractants such as platelet-activating factor, RANTES, and eotaxin.35 These studies suggest that CB2 and its endogenous ligand 2-AG may be potentially involved in allergic inflammation, accompanied by eosinophil infiltration, and this was demonstrated in a mouse model of contact dermatitis. Here, CNR2 is linked to contact dermatitis.