Other workers have demonstrated expression of CB1 and CB2 by bovine articular chondrocytes,20 synovia of patients with OA and RA,30 and human chondrocytes and fibroblast-like synoviocytes.19,39 Here, we demonstrate CB1 and CB2 localization within the cell membrane and cytoplasm of chondrocytes in all zones of cartilage and in the underlying osteocytes. The gene discussed is CNR2; the disease is rheumatoid arthritis.