GPLD1 and lysosomal storage disease: CADs have increased probability to cause drug-induced phospolipidosis (PLD),52 a lysosomal storage disorder characterized by the accumulation of phospholipids within the lysosome by unclear molecular mechanisms, leading to cellular stress.53–57 Indeed among the lysosomotropic drugs involved in the most transcriptionally similar drug-pairs (Table 1), there were also three known PLD-inducing drugs (astemizole, suloctidil and trifluoperazine).