CDK2 and cancer: Some drug classes (ATC classes N05, N06 and R06 including antihistamines and antipsychotics) are enriched for known PLDs.52, 54 Other classes cause global cellular stress responses not mediated by their physicochemical properties, but rather because of their direct molecular targets, such as anti-cancer compounds that block cell cycle (e.g., ATC class L01 composed of CDK2 and Topoisomerase I, II inhibitors).