ADAM12 and systemic sclerosis: Furthermore, we found that another gene is implicated in cell-cell and cell-matrix interactions, ADAM12, that resulted hypomethylated both in WS and in diffuse and limited SSc [18] and overexpressed (fold change equal to 1.3, P value = 0.022) in WS with respect to CTR when we analysed the GSE48761 dataset [30] (Fig. 3).