Anyway, the possibility for WS patients to be diagnosed as SSc was avoided as, based on 2013 ACR/EULAR classification criteria for SSc disease [52], serological analyses performed on subjects enrolled in the present study for anti-ANA and anti-ENA (anti-SS-A, anti-SS-B, anti-SM, anti-RNP, anti-SCL-70 and anti-JO-1) antibodies resulted negative. The gene discussed is RNPC3; the disease is Werner syndrome.