Among the strong, “rare” specificities, there was a number of potential autoantigens depicted in Figure 2A. Of these, LCN1 was reported as an autoantigen in Sjögren syndrome patients (30), and HMGB1 was reported to be associated with the production of anti-DNA autoantibodies in systemic lupus erythematosus (31). The gene discussed is HMGB1; the disease is Sjogren syndrome.