Further, periodontal tissues of the ligature-induced murine model of periodontitis display (a) significant increases in each subset of ILCs, an effect more marked for ILC2s and those with knockdown of AMPK and (b) increased expression of IL-33 but knockdown of AMPK is associated with significant increases in expression of ILC2s-generated cytokine: IL-33, IL-5, and IL-13. The gene discussed is IL33; the disease is periodontitis.