IL22 and periodontitis: Since CCR6 regulates expression of ILC3s-related cytokines (i.e., INF-γ, IL-17, and IL-22), it is likely that reduction in CCR6 expression by ILC3s of periodontitis model may reflect a compensatory mechanism to curtail inflammation by reducing potential for generation of INF-γ and IL-17 while increasing IL-22 generation, aspects that require further investigation.