CASP1 and early-onset autosomal dominant Alzheimer disease: Caspase-1 and IL-18 have also been shown to be produced in neurodegenerative diseases such as Alzheimer's disease and Multiple sclerosis (Losy and Niezgoda, 2001; Huang et al., 2004; Sutinen et al., 2012; Saco et al., 2014).