Caspase-1 and IL-18 have also been shown to be produced in neurodegenerative diseases such as Alzheimer's disease and Multiple sclerosis (Losy and Niezgoda, 2001; Huang et al., 2004; Sutinen et al., 2012; Saco et al., 2014). The gene discussed is IL18; the disease is early-onset autosomal dominant Alzheimer disease.