Our group has also provided compelling evidence that CSN8/CSN regulates not only the ubiquitin-proteasome system (UPS) but also the autophagic-lysosomal pathway for cardiac protein quality control and that CSN8-CKO initiated in perinatal and adult mice causes massive cardiomyocyte necrosis and heart failure (Su et al., 2011a,b, 2013). This evidence concerns the gene COPS8 and heart failure.