The induction of glutathione S-transferase and UDP-glucouronyl transferase (UGT) and the effect on bilirubin metabolism in rats was reported upon treatment with Scutellaria, Rheum officinale L., Artemesia, and Gardenia. The combination of extracts from the above mentioned plants is known as “Yin Zhi Huang” in the Chinese traditional medicine and is used in Asia for the management and treatment of neonatal jaundice via enhancement of bilirubin clearance (Yang and Lu, 1984; Chen and Guan, 1985; Dong et al., 1992; Elferink, 2004). Here, HPGDS is linked to neonatal jaundice.