MME and Stroke: Further candidates for the stroke-induced degradation of net components are aggrecanases, e.g., disintegrin and metalloproteinase with thrompospondin motifs (ADAMTS-1, 4, 8 and 15) and neprilysin (Cross et al., 2006; Lemarchant et al., 2013; Levy et al., 2015; Rossier et al., 2015).