RNA seq experiments have revealed that C9 repeat expansions result in altered gene expression in different brain regions from ALS patients as well as lymphoblastoid cell lines (Lagier-Tourenne et al., 2013; Sareen et al., 2013; Cooper-Knock et al., 2015; Prudencio et al., 2015). The gene discussed is C9; the disease is amyotrophic lateral sclerosis.