TARDBP and frontotemporal dementia: Moreover, TDP-43 has been shown to bind to, and regulate the expression of other genes involved in ALS, FTD, and related neurodegenerative diseases including FUS, Tau, ataxin 2, and progranulin (Polymenidou et al., 2011; Sephton et al., 2011; Tollervey et al., 2011).