It has been shown that ALS associated mutations in TDP-43 can disrupt axonal mRNA transport (Alami et al., 2014), RNP transport dynamics (Gopal et al., 2017), alter the splicing of RNA targets (Arnold et al., 2013), and influence stress granule dynamics (Dewey et al., 2011; McDonald et al., 2011; Liu-Yesucevitz et al., 2014). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.