The genes affected by coxibs and located within the loci showing SNP association for CAD are the vascular endothelial growth factor A (VEGFA), matrix metalloproteinase-9 (MMP9), breast cancer anti-estrogen resistance protein 1 (BCAR1) and the calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E). This evidence concerns the gene MMP9 and coronary artery disorder.