Based on these results and because of their novelty in this field, we further studied two targets that showed opposite effects on the barrier function: T-Cell Lymphoma Invasion And Metastasis 2 (TIAM2 - RhoGEF) and Synapse Defective1 (SYDE1 - RhoGAP). Here, SYDE1 is linked to T-cell non-Hodgkin lymphoma.