Interestingly, PEDF is generally regarded as a secreted protein but several immunohistochemical studies have reported significant quantities of PEDF in the nucleus of different cell types including retinal pigment epithelial cells, Y-79 retinoblastoma cells, NA neuroblastoma cells and hepatocarcinoma HepG2 cells23–26. The gene discussed is SERPINF1; the disease is neuroblastoma.