Moreover, Jones et al. demonstrated in a murine osteogenesis imperfecta model that MSC migration to bone and bone marrow is CXCL12-dependent and that CXCL12 upregulates CXCR4, demonstrating chemotaxis in vitro and enhancing engraftment in vivo36. The gene discussed is CXCR4; the disease is osteogenesis imperfecta.