Compared to RA-SR, CLIC1, CLIC2, and CLIC5 were significantly up-regulated (P < 0.05 in the comparison between RA-AF and RA-SR for CLIC1, CLIC2, and CLIC5, between LA-AF and RA-SR or RA-AF for CLIC5). This evidence concerns the gene CLIC5 and atrial fibrillation.