In this study, we have, for the first time, found that 1) alterations of CLIC1-6 by the RNA-Seq of transcriptomics and of CLIC1,4,5 by the iTRAQ of proteomics in the atrial tissue of rheumatic heart valve disease patients with AF in comparison to the patients with sinus rhythm. This evidence concerns the gene CLIC1 and atrial fibrillation.