All these reasons could be behind difficulties in detecting ADCY6 up-regulation in real tumour samples although there are couple of studies showing up-regulation of ADCY6 in tumour compared to normal tissues (e.g. osteosarcoma, prostate adenocarcinoma, pancreatic ductal adenocarcinoma and bladder cancer) (Fig. 6B). This evidence concerns the gene ADCY6 and urinary bladder carcinoma.