All these reasons could be behind difficulties in detecting ADCY6 up-regulation in real tumour samples although there are couple of studies showing up-regulation of ADCY6 in tumour compared to normal tissues (e.g. osteosarcoma, prostate adenocarcinoma, pancreatic ductal adenocarcinoma and bladder cancer) (Fig. 6B). Here, ADCY6 is linked to pancreatic ductal adenocarcinoma.