ADCY7 and hepatocellular carcinoma: Moreover, comparison of tumour versus normal tissues samples across Genevestigator, Oncomine (www.oncomine.org) and Expression Atlas (http://www.ebi.ac.uk/) databases showed up-regulation of the ADCY7 gene mostly in renal, breast, pancreas, gastric, ovarian cancer and hepatocellular carcinoma in several microarray and RNA-sequencing studies (Fig. 6A).