Our results suggested that rs10823108 AA genotype within SIRT1 has significant associations with about a 0.60-fold decreased risk of DN (OR = 0.60,95%CI:0.38–0.97) than GG genotype carriers, even after adjustments for age, gender, duration of diabetes, BMI, HbA1C,total cholesterol, triglycerides, HDL-C, LDL-C, history of Hypertension, DM family history, smoking and drinking status (OR = 0.57, 95%CI: 0.34–0.94), which is similar with the result in Japanese population17. The gene discussed is SIRT1; the disease is Hypertension.