FOXO1 and type 2 diabetes mellitus: Furthermore, we detected that Grs17446614Trs2721068 (OR:0.77, 95%CI:0.63–0.93) and Grs17446614Crs2721068 (OR:0.78, 95%CI:0.65–0.93) within FOXO1 could reduce the risk of DN in T2DM patients.