Multifactor Dimensionality Reduction (MDR) analysis was performed to analyze the gene-environment factors interaction with SNPs of SIRT1 and FOXO1(rs3818292, rs4746720, rs10823108, rs2721068, and rs17446614), age, gender, duration of diabetes, BMI, HbA1C, total cholesterol, triglycerides, HDL-C, LDL-C, Hypertension, DM family history, smoking and drinking status (Table 6). The gene discussed is SIRT1; the disease is diabetes mellitus.