The WA/BSA was significantly correlated with age in the third-, fourth-, fifth- and sixth-generation bronchi (ρ = 0.566, p < 0.001; ρ = 0.533, p < 0.001; ρ = 0.562, p < 0.001; and ρ = 0.556, p < 0.001, respectively, Table 4), but not with duration of asthma, blood eosinophil percentage, blood total IgE, percent predicted FEV1, or dose of inhaled corticosteroid. The gene discussed is IGHE; the disease is asthma.