Hepatic fibrosis markers (type IV collagen 7S, type III procollagen N-peptide [P-3-P], and fibrosis-4 [FIB-4] index) and the prothrombin time (international normalised ratio [INR]) were significantly higher and the platelet (PLT) count and serum albumin (ALB) concentration were lower in patients with C-CH than in those with NAFLD. This evidence concerns the gene F2 and Hepatic fibrosis.