Cultured neuroblastoma cells expressing TRKA or TRKC are not resistant to neurotrophin stimulation, per se, as exemplified by NGF or NT-3 treated TRKA or TRKC overexpressing SH-SY5Y cells, although neurothrophin treatment in those cells did not induce terminal differentiation19, 20. The gene discussed is NTRK1; the disease is neuroblastoma.