The corresponding cell lines LU-NB-2 and LU-NB-3 are thus MYCN amplified and express typical neuroblastoma markers, as shown previously10 and here by NCAM (also known as CD56) and NSE expression as well as chromogranin A (CHGA) and tyrosine hydroxylase (TH) protein expression, thereby confirming their neuroblastoma origin (Fig. 1a–c). The gene discussed is ENO2; the disease is neuroblastoma.