NOTCH3 and cancer: The capacity to seed metastasis is hypothesized to be a trait of cancer stem cells and while neuronal marker expression levels were in parity with those of the classical serum-cultured SK-N-BE(2) c neuroblastoma cells, PDX cells had higher expression of putative neuroblastoma stem-cell associated markers such as NOTCH1, NOTCH3 and C-KIT (also known as CD117 or SCFR) (Fig. 1b)13.