Since gene expression-based molecular subtypes have been shown to be enriched with some genomic alterations, such as EGFR amplification and HRAS-CASP8 co-mutations in the classical and basal subtypes, respectively [25, 26], we then tested the association of the RadR score with genomic instability and known recurrent genomics alterations in HNSCC. The gene discussed is CASP8; the disease is head and neck squamous cell carcinoma.