CCND1 and head and neck squamous cell carcinoma: We found the RadR score to be (1) associated with poor disease free-survival (DFS) in HPV-negative HNSCC patients treated by surgery and radiotherapy (with or without chemotherapy) but not in patients treated with surgery alone; (2) lower in the HPV-negative atypical molecular subtype and higher in the mesenchymal subtype; and (3) significantly associated with CCND1 amplification, fibronectin expression and seven biological hallmarks, including the ENT and the actionable “unfolded protein response” hallmarks.