In HPV-negative HNSCC, the epithelial-to-mesenchymal transition (EMT) via overexpression of fibronectin 1 (FN1), as well as activation of the epidermal growth factor receptor (EGFR) have been implicated in HNSCC radioresistance [9, 21–23]. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.