TGFB1 and head and neck squamous cell carcinoma: As expected, the mesenchymal subtype had higher ESs for the hallmarks “EMT”, “angiogenesis” and “TGFβ signaling”, as compared to other subtypes; whereas the classical subtype was characterized by higher ESs for the hallmarks “E2F targets” and “MYC targets”, thus suggesting that radioresistance may be driven by different hallmarks depending on the molecular subtype of a specific HPV-negative HNSCC.