A decreased RadR score was significantly associated with NSD1 (P < 0.0001) and PIK3CA (P = 0.0042) mutations, and to a lesser degree with TP63 amplification (P = 0.0108); while HNSCC harboring CCND1 amplification had a higher RadR score (P = 0.0354) (Fig. 4b). The gene discussed is PIK3CA; the disease is head and neck squamous cell carcinoma.