eNOS inhibition mechanism by proline rich tyrosine kinase 2 in response to fluid stress and insulin has also been reported [80]; Endostatin affects eNOS by dephosphorylating it at Ser-1177 residue inhibiting the endothelial cell migration [81] and endostatin is used for an anti-angiogenesis study in cancer [82]. This evidence concerns the gene NOS3 and cancer.