VEGFA and clear cell renal carcinoma: The frequent inactivation of the Von Hippel Lindau (VHL) gene in clear cell renal cell carcinoma, leading to increased levels of hypoxia inducible factor 1 (HIF1) and vascular endothelial growth factor (VEGF), provides the rationale for treatment with antiangiogenic receptor tyrosine kinase (rTKI) inhibitors.