Our conflicting results indicate that fractalkine levels and activity should be considered in future RV infection studies to better understand the precise kinetics, source and role of this unique dual soluble chemokine and adhesion factor expressed by multiple leukocyte and structural cells relevant in asthma to understand it’s likely role in recruitment of leukocytes to sites of inflammation and regulation of localised anti-viral immune responses in the bronchial mucosa [19–30]. This evidence concerns the gene CX3CL1 and asthma.