Regarding positivity of multiple RTKs, double positivity for EGFR and HER2 (EGFR+/HER2+/c-Met+ and EGFR+/HER2+/c-Met-) was significantly correlated with tumor size in addition to lymph node metastasis and UICC stage, which were also correlated with single EGFR positivity (Table 4). This evidence concerns the gene MET and neoplasm.