ERBB2 and metastatic malignant neoplasm in the lymph nodes: Regarding positivity of multiple RTKs, double positivity for EGFR and HER2 (EGFR+/HER2+/c-Met+ and EGFR+/HER2+/c-Met-) was significantly correlated with tumor size in addition to lymph node metastasis and UICC stage, which were also correlated with single EGFR positivity (Table 4).