Uno et al reported that the NF-κB-induced kinase (NIK) induced-mediated activation of non-canonical NF-κB signaling pathway (RelB/p52) plays a role in ovarian cancer progression through positively regulation of MMP-2 and MMP-9, resulting in enhanced NIK expression in ovarian cancer cells [18]. The gene discussed is NFKB1; the disease is ovarian cancer.