ACACA and leukemia: Furthermore, a recent study by Pardee et al. showed that the viability of HL60, Jurkat and K562 leukemia cells is greatly reduced upon inhibition of fatty acid synthesis with FASN inhibitor orlistat or ACACA inhibitor 5-(tetradecyloxy)-2-furoic acid [73], reinforcing the role of FASN and ACACA in lipid metabolism and cell proliferation.