EGFR and head and neck squamous cell carcinoma: A combination of EGFR TKI and celecoxib was studied for its effects on SCCHN cell lines and showed significant G1 arrest, apoptosis, and suppressed capillary formation of endothelium, leading to inhibited growth of all five cell lines tested, and suggesting there might be an additive or synergistic decrease in COX-2 expression [46].