Huang et al. confirmed that the converse is also true—TAK1 inhibition by 5Z-7-Oxozeaenol (5Z-O) was associated with suppression of downstream signaling and CCR7 downregulation in breast cancer cell lines, resulting in decreased tumor growth and lymphatic invasion when tested in vivo in mouse axillary lymph nodes [96]. This evidence concerns the gene CCR7 and breast carcinoma.