EGFR and head and neck squamous cell carcinoma: Treatment of human SCCHN cell lines with grape seed proanthocyanidins (GSP) significantly decreased cell viability, induced apoptosis and G1 arrest, inhibited expression of Cyclin D1/D2, and cyclin dependent kinases (CDK), downregulated E2F transcription factor, activated caspase-3, and reduced EGFR expression [60].