The results show that no significant relationships were observed between rs36084323 (PD-1.1 G/A) and rs2227981 (PD-1.5 C/T) polymorphisms and RA risk, neither in Caucasians nor Asians, while rs11568821 (PD-1.3 G/A) was observed to be significantly associated with risk of RA in Caucasians (OR = 1.18, 95% CI = 1.02–1.37). This evidence concerns the gene PDCD1 and rheumatoid arthritis.