reported the generation of tetrazole analogues of LY294002 active on the α isoform of PI3K only if delivered as a prodrug.25 Although different cancer cell lines were used, an EC50 value comparable with the one displayed by our compound, methyl 3‐{[4‐(2‐morpholino‐4‐oxo‐1,4‐dihydroquinolin‐8‐yl)‐1H‐1,2,3‐triazol‐1‐yl]methyl}benzoate (64), was reported [EC50=(2.1±1.1) μm on MCF‐7 versus (2.3±0.8) μm on PC3]. This evidence concerns the gene PIK3CA and cancer.