However, when we performed a similar exercise for the association of SNPs located within ± 500 bp of putative ERE motifs with breast cancer occurrence during 5 years of SERM therapy, 9 SNPs near but not within 7 putative EREs across the ZNF423 gene (Table 1) and 12 SNPs near but not within 6 putative EREs in the region surrounding the CTSO gene were associated with breast cancer occurrence with p < 1E-02 (Table 1). This evidence concerns the gene CTSO and breast cancer.