Interestingly, knockdown of H2A.Z.1, but not H2A.Z.2, led to altered expression of several candidate genes linked to psychiatric disorders such as autism and schizophrenia (Neurexin1, Shank3, CaMK2G, Vamp7, Gsk3b, Tuba8, Grm8, etc.). Here, GRM8 is linked to schizophrenia.