Interestingly, knockdown of H2A.Z.1, but not H2A.Z.2, led to altered expression of several candidate genes linked to psychiatric disorders such as autism and schizophrenia (Neurexin1, Shank3, CaMK2G, Vamp7, Gsk3b, Tuba8, Grm8, etc.). The gene discussed is GRM8; the disease is psychiatric disorder.