Interestingly, knockdown of H2A.Z.1, but not H2A.Z.2, led to altered expression of several candidate genes linked to psychiatric disorders such as autism and schizophrenia (Neurexin1, Shank3, CaMK2G, Vamp7, Gsk3b, Tuba8, Grm8, etc.). The gene discussed is TUBA8; the disease is autism.