SHANK3 and autism: PSD-95 is the anchoring protein encoded by Dlg4 and found exclusively in the postsynaptic density, while SHANK3 is another member of the postsynaptic density that is encoded by the high-confidence autism candidate gene Shank3. These two gene products were strongly reduced in neurons depleted of H2A.Z.1, but not H2A.Z.2 (Fig. 3D).