CALCA and Sepsis: In healthy adults, plasma PCT concentrations generally remain below 0.05 ng/mL and rapidly increase within 2–4 h in case of systemic bacterial infection (<0.25 to <0.5 ng/mL), sepsis (>0.5 to >2 ng/mL) and some non-infectious conditions (including trauma, surgery, burns, hyperthermia and neoplasms), remaining high until recovery (Table 1) [3], [4], [5].