Due to its peculiar biologic profile and “hormone-kine like” behavior PCT has been demonstrated to be a much more refined and reliable indicator of infection than other markers currently available, featuring a higher sensitivity and specificity to other markers such as such as C-reactive protein (CRP), cytokines (IL-6, IL-8, IL-10) and lactate [9], [16], [17], [18], [19], [20]. This evidence concerns the gene CALCA and infection.