Risk factors associated with development of AD pathology involve genetic predisposition (familial early-onset forms), allele forms of apolipoprotein E (i.e, ApoE-4 has the strongest impact), age, lifestyle, and converging evidence which suggests that many newly identified mutations are linked to altered APP processing leading to amyloidogenic pathogenesis [6, 7]. The gene discussed is APOE; the disease is Alzheimer disease.