P16 (ink4a) expression, which can be assessed immunohistochemically, is directly associated with HPV (7).Thus, this protein can help in the evaluation of CIN lesions (8).Cytokeratin 17 (CK17) is a type I (acidic) CK, its expression by mean of immunohistochemistry can assist in differentiating the grade of CIN lesions. Here, CDKN2A is linked to cervical squamous intraepithelial neoplasia.