In a rare subset of pemphigus, known as pemphigus herpetiformis (PH), in which IgG autoantibodies targeting Dsg1 seems to be related to the development of disease, it was suggested that these autoantibodies were able to induce overexpression of IL-8 in keratinocytes (47). Here, DSG1 is linked to pemphigus herpetiformis.