Along with IFN-γ and TNF-α, the main NK cells-derived cytokines that exert proinflammatory effects on other hematopoietic and non-hematopoietic cells in response to infection (34, 35), there is a growing list of soluble mediators that can also be released after activation of NK cells in different settings, including regulatory IL-5, IL-10, IL-13 (36–38), pro-inflammatory IL-17 (39), epithelial regenerative and protective IL-22 (40, 41), the growth factor GM-CSF (42), as well as chemokines MIP-1α, MIP-1β, IL-8, and RANTES (43–46). This evidence concerns the gene IL22 and infection.