The molecular mechanisms of ICD induction involves the exposition of calreticulin (CRT) on the surface of the dying tumor cells, the release of danger signals such as the high-mobility group box 1 protein (HMGB-1) and ATP, leading to the processing of tumor antigens by stimulated dendritic cells (DCs) and to Tc1 polarization of CD8+ T lymphocytes (24). Here, HMGB1 is linked to neoplasm.